Husein, Adam
(2011)
In vitro cytotoxicity evaluation of locally produced dental porcelain.
In vitro cytotoxicity evaluation of locally produced dental porcelain.
(Submitted)
Abstract
The in vitro cytotoxic potential of locally produced dental porcelain was evaluated in this study. The cellular response of
human osteoblast and MRC-5 cell lines were assessed using MTT assay by incubatiog with the fluid extract of dental
porcelain powder and dental porcelain discs (direct test). Aging process was carried out by submerging the discs into 3%
Bovine Serum Albumin (BSA) solution. Tests on extracts showed that the material was significantly different from the
control at a concentration of 250 mg/ml. Direct test showed thRt the material after aging was not significantly different
from the control with a mean (SD) of 89.2(13.4) %, whereas, it was significantly different from the control before
conditioning of BSA with a mean (SD) of 88.5(12.1) %. However, the dental porcelain caused mild suppression of
succinate dehydrogenase activity (<25%), which is considered to be accepted clinically and hence can be ranked as
being non-cytotoxic or mildly cytotoxic.
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