Lah, Nik Amin Sahid Nik
(2017)
A prospective double-blinded randomized controlled trial of the efficacy of haruan (channa striatus) spray on clean wounds.
Masters thesis, Universiti Sains Malaysia.
Abstract
Background
Channa striatus (Haruan), a fresh water fish indigenous to many tropical countries have long
been regarded as valuable food fish in the Far East. Several studies showed, the Haruan did
contain all the essential amino acids and fatty acids uniquely capable of accelerating the
wound healing and it has anti-nociceptive effect. However so far no human study been done
to assess the effectiveness of Channa striatus in wound healing. A prospective randomize
controlled trial has been conducted on the effect of Channa striatus Spray versus placebo on
clean wound to assess its pain control effect and cosmetic outcome.
Methodology
Hundred and two patients (102) underwent clean elective surgery; post-operatively they are
randomized into two group. One group received Channa striatus Extract spray (n=51)
another group receive placebo (n=51) on daily basis for 2 week. Then they were follow up on
2nd, 4th and 6th week to assess the pain control effect based on Visual Analog Pain Score
(VAPS) and cosmetic outcome based on Visual Analogue Cosmetic Scale (VACS), Wound
Evaluation Scale(WES) and Vancouver Scar Scale (VSS).
Result
The patient treated with Channa striatus spray displayed a better outcome in term of pain
control compared to placebo. During analysis using repeated measure ANOVA, there was
significant difference of patient’s pain score based on VAPS between Channa striatus spray
and placebo (F-stat(df) = 4.80 (2), p-value = 0.010). In term of cosmetic outcome it showed a
consistent significant better result in haruan spray group for all the 3 scoring system which is
VACS, (F-stat(df) = 2.68 (2) , p-value <0.001), WES (F-stat(df) = 3.09 (2), p-value = 0.048).
and VSS , F-stat(df) = 1.72 (2) , p-value = 0.011).
Conclusion
Our study suggest that application of Haruan Extract spray on clean wound has shown a
significant better pain score result and cosmetic outcome on week 2, week 4 and week 6
comparatively with placebo
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