Expression of P-selectin, TXA2, TGF-β1 and PDGF-AB in the Presence of Bioadhesive Chitosan Derivatives

Periayah, Mercy Halleluyah and Halim , Ahmad Sukari and Yaacob, Nik Soriani and Mat Saad, Arman Zaharil and Hussein, Abdul Rahim and Abdul Rashid, Ahmad Hazri (2014) Expression of P-selectin, TXA2, TGF-β1 and PDGF-AB in the Presence of Bioadhesive Chitosan Derivatives. Online International Interdisciplinary Research Journal, IV. pp. 5-14. ISSN 2249-9598

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Abstract

Chitosan is a natural macromolecular polysaccharide, derived from chitin extracted from the exoskeleton of some marine invertebrates. This study was designed to evaluate the expression of P-selectin, thromboxane A2 (TXA2), transforming growth factor-β1 (TGF- β1) and platelet derived growth factor-AB (PDGF-AB) using enzyme-linked immunosorbent assays (ELISAs). The chitosan derivatives utilized were 7% N,Ocarboxymethylchitosan (NO-CMC) (with 0.45 mL collagen), 8% NO-CMC, oligo - chitosan (O-C) and oligo -chitosan 53 (O-C 53). We found that O-C showed a significantly superior effect compared to NO-CMC in achieving hemostasis. Post-hoc multiple comparisons using Scheffe test indicated that p-values between the mean differences of all the assayed chitosan derivatives were not significant. However, our analyses successfully identified distinctions between the O-C and NO-CMC test groups and blood alone. These results may expand the understanding of the ability of chitosan derivatives to promote inflammatory responses and angiogenesis depending on their physical and chemical structures

Item Type:	Article
Uncontrolled Keywords:	Chitosan, P-selectin, TXA2, TGF-β1, PDGF-AB
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine T Technology > TP Chemical Technology
Divisions:	Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Article Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Article Zoom Profil Pakar (Expert Profile) > Abdul Rahim Hussein (Advanced Medical & Dental Institute)
Depositing User:	Administrator Automasi
Date Deposited:	23 Oct 2017 08:43
Last Modified:	23 Oct 2017 08:43
URI:	http://eprints.usm.my/id/eprint/37226

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