Assessment of Glycaemic Effect of Benincasa hispida Aqueous Extract in Streptozotocin Diabetic Rats

Zakaria, Fatariah and Wan Rosli, W. I. and Ng, Sze Han and Zain , Mohd Shazwan and Wan Ahmad, Wan Amir Nizam (2016) Assessment of Glycaemic Effect of Benincasa hispida Aqueous Extract in Streptozotocin Diabetic Rats. Health and the Environment Journal, 7 (1). pp. 1-12. ISSN 2180-1126

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Abstract

Benincasa hispida, Bh (winter melon) is a good source of natural sugars, amino acids, organic acids, mineral elements and vitamins. This study was designed to explore the glycaemic effect of Bh aqueous extract in diabetic rats. Male Sprague-Dawley rats (250-350g) were induced to become diabetic with streptozotocin (STZ, 45mg/kg intraperitoneal). The Bh aqueous extracts of 100, 250 and 500 mg/kg and metformin were administered through oral gavage to determine their effects on fasting blood glucose (FBG) and oral glucose tolerance test. The dose of 250 mg/kg was found to be the most effective dose and it decreased blood glucose level (BGL) by 11.8% in normal healthy rats after 6H of administration. The same dose also caused a marked reduction in BGL of 33.1% in normal rats, 38.7% in severe diabetic rats and 64.7% in mildly diabetic rats in OGTT after 3H of oral administration of the extract. The changes of BGL were not significant compared to normal rats. It shows that the extract is diabetic-friendly since the blood glucose levels were stable throughout the study period. These trends of BGL reduction show that Bh aqueous extract is diabetic friendly.

Item Type:	Article
Uncontrolled Keywords:	Diabetes mellitus; glucose tolerance test; hypoglycaemic; rats; Benincasa hispida.
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine T Technology > TX Home economics > TX341-641 Nutrition. Foods and food supply
Divisions:	Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Kesihatan (School of Health Sciences) > Health and the Environment Journal Penerbit Universiti Sains Malaysia (USM Press) > Health and the Environment Journal Zoom Profil Pakar (Expert Profile) > Wan Rosli Wan Ishak (Health Sciences)
Depositing User:	Administrator Automasi
Date Deposited:	10 Jan 2017 09:46
Last Modified:	28 Aug 2017 05:02
URI:	http://eprints.usm.my/id/eprint/31523

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