Immunomodulatory Effects of Oyster Mushroom (Pleurotus sajor-caju) Extract In Balb/c Mice.

Nurul, A. A. and Jonathan, M. A. and Jamaruddin, M. A. and Wan Rosli, W. I. (2014) Immunomodulatory Effects of Oyster Mushroom (Pleurotus sajor-caju) Extract In Balb/c Mice. Research & Reviews in Pharmacy and Pharmaceutical sciences, 3 (3). pp. 27-32. ISSN 2320-1215

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Abstract

Pleurotus sajor-caju (oyster mushroom, PSC) is widely used in culinary due to its various benefits on human health. However, no study has been reported on its immunomodulating properties. Cultivated mushroom powder was used for hot aqueous extraction using Soxhlet technique. The PSC extract was suspended into CMC and prepared into 3 groups: 0.2 g/kg, 1g/kg and 2g/kg. Balb/c mice were orally fed daily for 21 consecutive days. Treatment of mice with various concentrations of PSC showed increased populations of CD3+/CD4+, CD3+/CD8+, CD14+ and CD 19+ cells. Interestingly, PSC-treated mice demonstrated significant increase in CD3+/CD4+ and CD19+ cells. Most importantly, mice treated with PSC showed improved CD4+/CD8+ ratio; which indicated potential immunostimulating activity by PSC. In addition, no physical changes and signs of mortality could be detected from PSC-treated mice. The results suggest that PSC may improve general immune status when consumed consistently as a daily food option.

Item Type:	Article
Uncontrolled Keywords:	Pleurotus sajor-caju, oyster mushroom, immunomodulatory, lymphocytes, Balb/c mouse
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine T Technology > TP Chemical Technology > TP368-456 Food processing and manufacture T Technology > TX Home economics > TX341-641 Nutrition. Foods and food supply
Divisions:	Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Kesihatan (School of Health Sciences) > Article Zoom Profil Pakar (Expert Profile) > Wan Rosli Wan Ishak (Health Sciences)
Depositing User:	Administrator Automasi
Date Deposited:	09 Mar 2017 03:00
Last Modified:	28 Aug 2017 05:02
URI:	http://eprints.usm.my/id/eprint/27595

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