Mohamed Yusoff, Syahirah (2020) Recombinant Factor Viia In Massive Bleeding At Hospital Universiti Sains Malaysia. Masters thesis, Universiti Sains Malaysia.
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Abstract
INTRODUCTION: Massive bleeding is a salvageable cause of mortality and morbidity. Vigorous haemostatic resuscitation carries its own benefit and risk. This study aims to explore the indications and outcomes of non-haemophilia patients treated with and without rFVIIa during massive bleeding in Hospital Universiti Sains Malaysia (HUSM) over a 6-year-period. METHODS: A retrospective cohort analysis from year 2013 to 2018 was conducted. One hundred forty massive bleeding patients who were treated with and without rFVIIa during massive bleeding and fulfilled the inclusion and exclusion criteria were recruited and evaluated. Their laboratory investigations (haemoglobin, PT, aPTT and INR), Sequential Organ Failure Assessment (SOFA) score and clinical outcomes were explored. RESULTS: The primary cause for rFVIIa administration was surgical causes (57.1%). Comparison of 30 day survival within surgical and medical causes of massive bleeding showed a higher survival rate among surgical causes especially in lower SOFA score. Besides that, in surgical causes, the survival rate is similar (57.5%) despite significant difference of the mean SOFA score (p=0.006). When we compare the medical causes of massive bleeding the treatment group have poorer outcome (p=0.003). Reduction of blood product requirement were also noted in the treatment group. CONCLUSION: rFVIIa may be more beneficial to be used in surgical causes of massive bleeding, especially when patients still have lower SOFA score. Besides, no benefit of rFVIIa was shown among medical causes of bleeding, regardless of the SOFA score.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | NOR HASHIMY BIN ABDULLAH |
| Date Deposited: | 19 May 2026 03:23 |
| Last Modified: | 19 May 2026 03:23 |
| URI: | http://eprints.usm.my/id/eprint/64238 |
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