Wahab, Mohd Ghaddafi (2022) Effectiveness of deep brain stimulation (DBS) surgery and its clinical outcomes among parkinson disease patients in Hospital Universiti Sains Malaysia (HUSM). Masters thesis, Universiti Sains Malaysia.
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Abstract
Title : Effectiveness of deep brain stimulation (DBS) surgery and its clinical outcomes among Parkinson Disease patients in Hospital Universiti Sains Malaysia (HUSM) Background: Deep brain stimulation (DBS) has proven itself as a viable treatment option for individuals with Parkinson Disease (PD) who exhibit bothersome motor fluctuations and dyskinesias that are resistant to standard pharmacological treatments. At present, only a limited amount of information on the efficacy and safety of DBS for the treatment of individuals with PD is available in Malaysia. As such, we sought to evaluate its efficacy and post-DBS complications at our hospital, Hospital Universiti Sains Malaysia (HUSM). Methodology: We used a retrospective cohort design and we gathered secondary data on Parkinson disease patients who had (DBS) surgery at our hospital from 2008 to 2021. We assessed the efficacy of DBS at six- and twelve-months post-surgery using the UPDSR III score and Activities of Daily Living (ADL). Our objectives were determined using the Wilcoxon rank sum and the McNemar Test. Results: This study included a total of 15 participants. At six months, either with or without the medication, DBS treatment resulted in a statistically significant decrease in the UPDRS III score. However, no substantial changes were seen over a 6- to 12-month follow-up period. Additionally, we discovered a statistically significant difference in the percentage of ADL performed without drug post DBS. Meanwhile, none of our patients had cerebral haemorrhage after DBS, although three acquired infection post-operatively. Conclusion: In Malaysia, DBS has been shown to be a safe and effective short-term therapy for persons with Parkinson's disease. Additional research is needed to demonstrate that early DBS decreases the need for and complexity of PD medicines while delivering long-term motor improvement compared to normal medical treatment.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Parkinson Disease, Deep Brain Stimulation |
| Subjects: | R Medicine R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RD Surgery > RD520-599.5 Surgery by region, system, or organ |
| Divisions: | Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Thesis |
| Depositing User: | MUHAMMAD AKIF AIMAN AB SHUKOR |
| Date Deposited: | 05 May 2026 23:43 |
| Last Modified: | 11 Aug 2026 07:52 |
| URI: | http://eprints.usm.my/id/eprint/64079 |
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