Aizuddin, Maryam Jameelah (2021) Red Blood Cells Transfusion Practice In Paediatric Cardiac Surgery At The National Heart Institute (Ijn) Of Malaysia. Masters thesis, Universiti Sains Malaysia.
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Abstract
Introduction: Allogenic blood transfusion among paediatric cardiac surgery conducted under cardiopulmonary bypass (CPB) remains very frequent and is associated with potential adverse consequences, including postoperative morbidity. This study aims at identifying the predictive factors associated with perioperative red blood cells (RBC) transfusion and finding its association with postoperative outcomes, in order to promote patients' effective management and guide clinicians to decide on judicious blood transfusion. Methods: This cross-sectional retrospective study, conducted in IJN, involved 243 paediatric patients with cardiac surgery less than 18 years of age who had CPB surgery done in 2018. Results: Preoperatively, 4.5% of patients received RBC transfusion with significant predictor for transfusion; haemoglobin (Hb) with mean value of 8.3 to 9.8 g/dL. Intraoperatively, cumulative of 99.2% of patients received RBC transfusion with predictive factors for transfusion in high RBC transfusion subgroup; young age, low body weight, RACHS-1 scores of ≥ 3 and had longest CPB time compared to other groups. RBC transfusion status pre- and intraoperatively was found not to influence postoperative RBC transfusion status significantly. Our analysis showed that 25.9% of our studied population received low RBC transfusion during the postoperative period, while another 11.5% received high RBC transfusion. The CBP time and surgery duration were profoundly longer in the postoperative high RBC transfusion subgroup. Longest mechanical ventilation is significantly associated with preoperative low RBC transfusion subgroup and other covariates like lower body weight and longer CPB time. Longer duration of PICU stay was correlated with low preoperative and high postoperative RBC transfusion, lower body weight, RACSH-1 score >2 and longer CPB time duration. Conclusion: The predictive transfusion factors identified in relation to operative time were unique to each phase. This study also concluded that certain perioperative RBC transfusion status showed a significant association with selected postoperative outcomes, duration of mechanical ventilation and length of the PICU stay.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine |
| Divisions: | Institut Perubatan & Pergigian Termaju (Advanced Medical & Dental Institute (AMDI)) > Thesis |
| Depositing User: | NOR HASHIMY BIN ABDULLAH |
| Date Deposited: | 17 Apr 2026 02:57 |
| Last Modified: | 17 Apr 2026 02:57 |
| URI: | http://eprints.usm.my/id/eprint/63933 |
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