Gheshmi, Nasreh Shamsi Poor (2024) Assessment Of Clinical Outcomes And Safety Profile Of Biologic And Targeted Disease Modifying Anti-Rheumatic Drugs (Dmards) For Rheumatoid Arthritis Management In Malaysian Population. PhD thesis, Perpustakaan Hamzah Sendut.
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Abstract
Rheumatoid arthritis (ra) is a chronic autoimmune disorder characterized by inflammation of the synovial tissue in the joints, resulting in joint damage and subsequent physical disability. In recent years, significant advancements in the treatment of ra have been witnessed, primarily due to the introduction of biologic and targeted synthetic disease-modifying antirheumatic drugs (dmards). However, despite their effectiveness, they possess clinically unfavourable consequences. The aim of this thesis is to assess the efficacy and safety of biologic and targeted synthetic dmards therapy on the clinical outcomes of malaysian individuals with ra. To meet the objective of the thesis, retrospective and prospective, longitudinal study was conducted at hospital putrajaya and hospital serdang, malaysia. Ra patients 18 years old and above with biologic and targeted synthetic dmards therapy were screened and enrolled. The specifically designed data collection form was used to obtain required information. Obtained data were analysed by using statistical package for social sciences (spss version 26). Out of 270 patients with biologic and targeted synthetic dmards therapy included in the study, female comprises the majority of study population (70.7%) and 51.1 % malay. More than half of the patients were biologic naïve (54.8%), and 55.9% received monotherapy. During 12 months follow up, statistically significant reduction of disease activity score (das28) was observed (f (2.97, 701.48) = 255.91, p < 0.001).
| Item Type: | Thesis (PhD) |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica |
| Divisions: | Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis |
| Depositing User: | Mr Hasmizar Mansor |
| Date Deposited: | 25 Feb 2026 01:21 |
| Last Modified: | 25 Feb 2026 01:21 |
| URI: | http://eprints.usm.my/id/eprint/63651 |
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