Shtaiwi, Amneh Mohammad (2018) Computational Design And Investigation Of New Benzophenones And Benzophenone Imines Inhibitors For Breast Cancer. PhD thesis, Universiti Sains Malaysia.
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Abstract
The computational methods of protein-ligand interactions are core components in drug design and modem drug discovery. This study attempted to design and investigate the interactions of new human estrogen receptor (hERa) inhibitors to treat breast cancer cells using molecular modeling approach. The proposed inhibitors were designed by replacing the triarylethylene estrogenic scaffold found in the synthetic inhibitor 4-hydroxytamoxifen (4-0HT) with triarylimine Schiff bases.
| Item Type: | Thesis (PhD) |
|---|---|
| Subjects: | Q Science > QD Chemistry > QD241-441 Organic chemistry |
| Divisions: | Pusat Pengajian Sains Kimia (School of Chemical Sciences) > Thesis |
| Depositing User: | Mr Aizat Asmawi Abdul Rahim |
| Date Deposited: | 24 Sep 2025 02:30 |
| Last Modified: | 24 Sep 2025 02:30 |
| URI: | http://eprints.usm.my/id/eprint/62857 |
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