Korindasamy, Novline Yuvashnee
(2023)
Ketum (Mitragyna Speciosa Korth.)
Consumption, Lipid Profile And
Electrocardiogram (Ecg)
Abnormalities.
Masters thesis, Universiti Sains Malaysia.
Abstract
Ketum (Mitragyna speciosa Korth.) a native medicinal plant of Southeast Asia,
has been used in Malaysia for decades for its unique curative properties. Given its
broad therapeutic properties and increasing utility, ketum’s long-term safety
profile, especially on its cardiotoxicity risk remains poorly investigated in regular
ketum users. Given this research limitation, this study aims to evaluate the
electrocardiogram (ECG) abnormalities and lipid profile between regular ketum
users and healthy control subjects. A total of 200 respondents (n=100 regular
ketum users and n=100 healthy control subjects) were recruited through
convenience sampling from the northern peninsular state of Penang for this clinical,
cross-sectional study. All were required to undergo an ECG evaluation, and blood
samples were also drawn to characterize the respondent’s lipid profile. All males,
a majority were Malays (97%, n=194/200), and the samples mean age in this study
was 33 years (SD=6.7), while ketum users mean duration of ketum use was 6.4
years (SD=4.31). Ketum users mean systolic and diastolic blood pressure rates
were 132.9 beats per minute (SD=17.3) and 77.1 beats per minute (SD=11.1),
respectively.
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