The role of specific helicobacter pylori virulence and host genetic factors in gastroduodenal disease

Hasan, Habsah (2016) The role of specific helicobacter pylori virulence and host genetic factors in gastroduodenal disease. Project Report. Pusat Pengajian Kesihatan. (Submitted)

[img]
Preview
 PDF
Download (12MB) | Preview

Abstract

The aim of this study was to determine the distribution of H. pylori virulence genes (cagA, babA2, SabA and dupA) and cagA EPIYA motifs and correlation with clinical outcomes. It also explored the presence of SNPs in genetic variants which may be associated with susceptibility or protective to H. pylori infection. H. pylori cagA, babA2, sabA and dupA genes in H. pylori dyspeptic patients were 69.5%, 41.0%, 43.8% and 22.9% respectively. Majority of Chinese patients were predominantly infected with cagA type A-B-D East Asian strain (88.9%) while cagA type A-B-C Western strain (82.8%) was predominantly detected in Indians while Malays have mixed strain. The present study identified SNPs rs3770521 (P=1.33 x’s) of XRCC5 gene, rs7042986 of SMARCA2 (P=0.0001) and rs10860808 (P=0.0002) of DRAM1 gene as susceptible SNPs to H. pylori infection among gastritis patients of Indian, Malay and Chinese respectively. This study also identified two protective SNPs rs1809578 (P=9.85x 10 ’6) of gene BANK1 and rs3776349 (P=0.0001) of gene ARHGAP26 among H. pylori gastritis patients of Indian and Malay respectively. In conclusion, the current GWAS study revealed five novel SNPs that may be associated with susceptibility and protection of H. pylori gastritis in this population.

Item Type: Monograph (Project Report)
Uncontrolled Keywords: helicobacter pylori virulence
Subjects: Q Science > Q Science (General)
R Medicine > RC Internal medicine > RC109-216 Infectious and parasitic diseases
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Kesihatan (School of Health Sciences) > Monograph
Depositing User: Mr Husnan Budin
Date Deposited: 27 Mar 2024 07:02
Last Modified: 27 Mar 2024 07:02
URI: http://eprints.usm.my/id/eprint/59772

Actions (login required)

View Item View Item
USM Repository is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.
Share