Hosseinzadeh Bajgiran, Mohammad Morteza
(2022)
Transcriptomics Analysis Of Coding Genes And Long Non-Coding Rnas In Ageing In Drosophila Melanogaster.
Masters thesis, Perpustakaan Hamzah Sendut.
Abstract
Ageing is characterised by the loss of physiological and cellular functions, the
loss of tissue structure, and deterioration of molecular interactions, leading to chronic
diseases such as diabetes, cancers, neurodegenerative diseases, and other age-related
diseases. Due to the genetic conservation, the genes and pathways underlying ageing
were found to have comparable pattern across different species. These genes and
pathways have been categorised into nine cellular and molecular hallmarks, namely,
genomic instability, telomere attrition, loss of proteostasis, mitochondrial dysfunction,
epigenetic alterations, deregulated nutrient sensing, stem cell exhaustion, cellular
senescence and altered intercellular communication. The main objectives of this
research are to understand how the expression levels of coding genes change during
ageing and to identify lncRNAs involved in the process of ageing. To determine the
best time points that represent young adult, middle age adult and old adult of D.
melanogaster, the survival curve was determined and accordingly three time points,
day 1, day 30, and day 60, were chosen.
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