Kumaran, Kesevan Rajah
(2021)
Effects Of Syzygium Polyanthum (Wight) Walp. Leaf Extract With Potential Cholinergic Activity On Cognitive Function In Chronic Cerebral Hypoperfusion Rat Model.
PhD thesis, Universiti Sains Malaysia.
Abstract
Vascular dementia (VaD), is the most common type of dementia in the ageing population, initiated by chronic cerebral hypoperfusion (CCH). Cholinergic system dysfunction in the central nervous system (CNS) has been recognized as one of the main reasons for learning and memory impairment in VaD patients. Therefore, medications that restore the level of acetylcholine (ACh) neurotransmitter by inhibiting cholinesterase activity have been proposed as a potential candidate to treat VaD patients. Present study was conducted to evaluate the effect of four methanol plant extracts with anti-cholinesterase activity in POBCCA rats. The selected plant extracts were Coccoloba uvifera (stems), Mimusops elengi (leaves), Syzygium aqueum (leaves) and Syzygium polyanthum (leaves). The effects of these plants (100 and 200 mg/kg) on learning and memory were evaluated using novel object recognition (NOR) and morris water maze (MWM) tests. The behavioral tasks results revealed S. polyanthum (100 and 200 mg/kg) and S. aqueum (200 mg/kg) extracts improved short- (p < 0.05) and long-term (p < 0.05) recognition memories during NOR. Besides that, M. elengi and S. aqueum (200 mg/kg) along with S. polyanthum (100 and 200 mg/kg) extracts improved spatial learning (day 4: p < 0.05; day 5: p < 0.05) and S. polyanthum exract (100 and 200 mg/kg) improved reference memories (p < 0.05) in MWM test.
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