Yaacob, Najib Majdi
(2010)
Metabolic syndrome study among Malay national service
trainees in Kelantan.
Masters thesis, Universiti Sains Malaysia.
Abstract
Metabolic syndrome is a constellation of risk factors which
increases the risk for diabetes and cardiovascular diseases consisting of obesity,
hypertension, hypertriglyceridemia, low level of high density lipoprotein cholesterol
and hyperglycemia. As the prevalence of obesity increases, the prevalence of
metabolic syndrome is also increasing at an alarming trend in numerous populations.
C-reactive protein and adiponectin are two important biochemical markers which is
said to have association with the development of metabolic syndrome, however the
exact mechanism is not yet well understood. The objectives of this study were to describe the prevalence of metabolic syndrome among National Service trainees in Kelantan and determine the
association between components of metabolic syndrome (BMI, WC, WHtR, SBP,
DBP, TG, HDL-C, fasting blood glucose and fasting insulin), C-reactive protein and
adiponectin levels. A cross-sectional study was conducted in 2009 involving 156
National Service trainees in Kelantan. As no single ‘gold standard’ criteria is
available to diagnose metabolic syndrome in Asian adolescents, we describe the
prevalence using four different criteria namely the International Diabetes Federation
definition of metabolic syndrome for children and adolescents, the modified NCEP
ATP III criteria for Asians, the criteria used previously in Indian adolescents population (Vikram et al., 2006) and criteria previously used in Korean adolescents
population (Kim et al., 2007). Association between components of metabolic
syndrome with C-reactive protein and adiponectin was studied using simple and
multiple linear regression and correlation between adiponectin and C-reactive
protein was studied using Pearson Correlation. The prevalence of metabolic syndrome among National Service trainees
in Kelantan is 1.28% when IDF criteria and NCEP ATP III criteria was used and
0.64% when criteria by Vikram et al. and Kim et al. was used. There is significant
positive linear association between C-reactive protein levels and Body Mass Index in
overall, both male and female adolescents. Significant negative linear association
was observed between adiponectin levels, Body Mass Index and waist to hip ratio in
overall subjects. When analysis was divided according to gender, there is a
significant negative association between adiponectin and Body Mass Index while in
female there is a significant positive linear association between adiponectin and high
density lipoprotein cholesterol. No significant correlation was found between Creactive
protein and adiponectin levels. We conclude that the prevalence of metabolic syndrome among
National Service trainees in Kelantan is low compared to other study population,
however in view of ethnicity-related characteristics, the cut-off points used might not
be suitable for our study population. Adiponectin and C-reactive protein was proven
to have significant association with several components of metabolic syndrome. Further study need to be conducted to better understand the exact mechanism of
metabolic syndrome especially among Malaysian adolescents.
Actions (login required)
 |
View Item |
