Ernie Haryantle, Shaharudin
(2010)
A study on the effect of normal saline
And dextrose saline solution infusion
During labour: a comparative study.
Masters thesis, Universiti Sains Malaysia.
Abstract
To evaluate the effects of intrapartum 0.9% Nonnal Saline infusion and Dextrose Saline
solution on the fetal and maternal outcome. A prospective controlled study in which low risk nullipara with singletons in active
labour at tenn were randomized to receive intravenously either Nonnal Saline or
Dextrose Saline as the maintenance fluid during active labour. Antepartum and
intrapartum factors were recorded. Maternal and neonatal outcomes were analyzed. Of 400 subjects enrolled, 395 met inclusion criteria and completed the study. There were
no statistical differences between the two groups regarding maternal age, maternal
weight on admission and gestational age. The difference in second stage duration was
also not significant. Newborn birth weight, gender, incidence of meconium and Apgar
scores were not statistically different. The difference in the median of labour length
between the Nonnal Saline and Dextrose Saline was statistically significant (340 ± 112
min vs 300 ± 110 min; p=0.04). There were significant differences between the Nonnal
Saline group and Dextrose Saline group in cord blood pH values (7.25 ± 0.04 vs. 7.28 ±
0.04; p=O.OOl), PCDl values (45.38 ± 4.13mmHg vs 41.05 ± 4.68 mmHg; p=O.OOl) and
base excess (-6.2 ± 1.2 mmo11L vs. -4.5 ± 1.4 mmol/L;p=O.OOI). Administration of a Dextrose Saline solution was associated with lower incidence of
umbilical cord acidemia, reduced the need for augmentation and shortened the labour
duration in term nullipara subjects in active labour.
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