Sirajudeen, K.N.S.
(2012)
The role of oxidative stress and
the effect of antioxidant (vitamin
e & melatonin) in the development
of hypertension in spontaneously
hypertensive rats.
Other.
Pusat Pengajian Sains Perubatan.
(Submitted)
Abstract
The glutathione (GSH) system plays a vital role In preventing oxidative stress, and an
Imbalance of oxidant/antioxidant system has been linked to the pathogenesis of hypertension. The
aim of this study was to investigate the status of the GSH system in the kidney of spontaneously
hypertensive rats (SHR). Components of the GSH system, including glutathione peroxidase (GPx),
glutathione reductase (GR), glutathione-S-transferase (GST) and total GSH content, were measured in
the kidneys of 4, 6, 8, 12 and 16 weeks old SHR and WKY rats. Systolic blood pressure of SHR was
significantly higher from the age of 6 weeks onwards compared to age-matched WKY rats. GPx activity
In the SHR was significantly lower from the age of 8 weeks onwards when compared to that In agematched
WKY rats. No significant differences were evident ln.the GPx-1 protein abundance and Its
relative mRNA levels, GR. GST activity and total GSH content between SHR and age-matched WKY rats.
The lower GPx activity suggests of an Impairment of the GSH system in the SHR, which might be due to
an abnormality In Its protein rather than non-availability of a cofactor. Its role In the development of
hypertension in SHR however remains unclear.
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