Chew Keng, Sheng
(2012)
A randomized controlled trial on the
use of budesonide/formoterol
(symbicort) as an alternative reliever
medication for mild to moderate
asthmatic attack in adult patients in
Emergency Department, HUSM.
Other.
Pusat Pengajian Sains Perubatan.
(Submitted)
Abstract
This study is done to evaluate the effectiveness of symbicort (a combination of
formoterol and budesonide) as an alternative reliever in mild to moderate acute
axacerbation of bronchial asthma Patients who fulfilled the criteria of mild or moderate asthmatic attack and agreed
to participate in this study were randomly assigned to either nebulized salbutamol or
symbicort turbuhaler as the treatment. Objective and clinical parameters such as
respiratory mte (RR), oxygen saturation (SP02), peak expiratory flow mte (PEFR) and
fraction of exhale nitric oxide (FENO) were recorded before and after treatment.
Subjective assessment using visual analog score and 5-point Likert scale were also taken.
The patients were reassessed 15 minutes later for need of further treatment After randomization, 17 out of 32 patients were chosen to receive nebulized
salbutamol and another 15 patients to receive symbicort. There were significant
improvements in respiratory mte (RR), oxygen satumtion (SP02) and PEFR in patients
received symbicort turbuhler (p=O.OOI, p=0.027 and p=<O.OOJ respectively). This result
is significant in patients receiving nebulized salbutamol as well. When compared between
these two groups, no significant difference was demonstmted.
In terms of subjective parameters using 'Visual Analog Score' and '5-point
Likert Scale' of breathlessness, it also showed that there were no significant difference in
patients who received symbicort turbuhaler or nebulized salbutamol. Symbicort has the potential to be used as an alternative treatment for patients with
mild to moderate exacerbation of asthma as there were no significant difference in terms
of objective and subjective improvements at least for the first 15 minutes.
Actions (login required)
 |
View Item |
