Zain, Anuar Md.
(2007)
The Evaluation Of The Toxic Effect Of And Its Paraquat Mechanism Of Action On
Reproductive System Of Male Rats.
Masters thesis, Universiti Sains Malaysia.
Abstract
Paraquat‘r") - PQ (1.1’ — dimethyl 4.4' - bipyridillium dichloride) is a nonselective
contact herbicide. Its herbicidal and toxicological properties are
dependent on the ability of the parent cation to undergo a single electron
addition to form a free radical. The present study was conducted to evaluate
the toxic effect of low dose of PO and its mechanism of action on the
reproductive system of adult male rats. Two routes of administration were
selected; oral and dermal which are the most common exposure routes in
human being Groups of six male Sprague-Dawley rats (n=6) were orally
gavaged in selected dose of 2mg/kg. 5mg/kg and 20mg/kg (1/80, 1/32 and 1/8
of oral LD50) and dermally applied in selected dose of 6mg/kg, 15mg/kg and
30mg/kg (1/15, 1/6. and 1/3 of dermal LD50) for five consecutive days
separately and scheduled for 7, 28. 42, 84 and 105 days for oral, and 7, 14.
28 and 42 days for dermal applications in separate groups after the last dose,
Body weight did not show any change in the treated groups compared to the
control.
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