Ellyda, Muhammed Nordin
(2009)
A record review study on the successfulness of radioiodine ablation
in postoperative well differentiated
thyroid carcinoma patients using 100 mci
of 131i in HUSM.
Masters thesis, Pusat Pengajian Sains Perubatan.
Abstract
A record revtew study on the success of radioiodine ablation in postoperative well
differentiated thyroid carcinoma patients using 100 mCi of 131i in HUSM. Well differentiated thyroid carcinoma is curable when discovered at an early stage. Postoperative
radioiodine ablation is very useful. Its management. however. is often a challenge
because there have been no prospective randomized trials and the optimal dose for
successful single ablation is still a controversy. However. many published data showed a
single high dose ablation is statistically significant in the treatment of post-operative well
differentiated thyroid carcinoma. The objectives of this study are I) to detennine the prevalence of success of single dose of
radioiodine ablation using I 00 mCi of 131 I. 2) to cotTelate successful ablation with other
factors and 3) to determine the prevalence of patients that developed distant metastases
after ablation therapy. This is a record review study over a period 10 years (1st January 1997 till 31st December
2007). A total of214 samples that fulfilled the inclusion criteria were studied. The attached
formal reported result of first whole body scan and related associated factors were
reviewed and the required data were retrieved and studied by the main researcher. The prevalence of successful ablation in our population was 54.2% which is slightly lower
than that of reviewed published data from other countries. Total thyroidectomy was found
to be the only significant associated factor in this study. The prevalence of patients
developed metastases after initial ablation was 23.8% with lymph node being the
commonest site of metastases. In this study, we conclude that the present ablative dose of 100 mCi is effective in the
treatment of well differentiated thyroid carcinoma remnants. We also found that only the
type of thyroid surgery had a significant association with the outcome of radioiodine
ablation.
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