Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity

Althiabat, Mohammad Gasem Mohammad (2020) Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity. Masters thesis, Universiti Sains Malaysia.

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Abstract

The goal of this thesis is to design new FA analogues with higher selectivity to bind with FRα. Fifty FA-analogues with variant heterocyclic rings were designed and studied for their interaction with FRα. Docking results showed 20 out of the 50 FA-analogues showed higher binding affinity than methotrexate (MTX) and the parent folic acid (FA) towards FRα.

Item Type: Thesis (Masters)
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis
Depositing User: Mr Aizat Asmawi Abdul Rahim
Date Deposited: 21 Jul 2022 01:53
Last Modified: 21 Jul 2022 01:53
URI: http://eprints.usm.my/id/eprint/53495

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