Farhan, Ahmed Bassam
(2020)
Investigation Of Dissolution Performance And Physical Characterization On Development Of Solid Dispersion Dosage Form.
PhD thesis, Universiti Sains Malaysia.
Abstract
Solid dispersion (SD) formulation has attracted much attention due to its
potential in enhancing dissolution performance of poorly soluble active
pharmaceutical ingredients (API). However, an overview of the dissolution
performance of SDs implies inconsistent degree of dissolution improvement of
poorly soluble APIs in SD. Therefore, the main objective of this study is to
determine the criteria of a good carrier system and drug candidate for enhanced
dissolution performance of a solid dispersion system for a poorly soluble drug and
dosage form consideration particularly the impact of compaction. To achieve these
objectives, several SD systems were prepared in this study by spray drying and
quenched
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