Amelah Mohamed, Abdul Qader
(2008)
A study on the association of serum lipid profile with retinal hard exudates
among patients wim type 2 diabetes mellitus
in Hospital USM.
Masters thesis, Universiti Sains Malaysia.
Abstract
Retinal hard exudate is a component of diabetic retinopathy which is
formed due to breakdown of the inner blood retinal barrier, as a process of
microangiopathy.
Objectives: To study the association between lipid profile and retinal hard exudates in
diabetic retinopathy and the association between oxidized-LDL with systemic diseases
among type 2 diabetic patients.
Methodology: A cross sectional study was conducted in 40 patients with diabetic
retinopathy and another 40 patients without diabetic retinopathy. Demographic data was
collected and comprehensive ocular examination was performed. Nine ml venous blood
was taken for fasting serum cholesterol, triglycerides, HDL, LDL, ox-LDL, and for
HbAIC·
Results: The mean serum cholesterol level was 5.9 (1.86) mmol/L in diabetic
retinopathy group compared to patients without retinopathy 5.0 (1.03) mmoi/L (P=
0.001). The mean serum LDL was 3.6 (1.69) mmol/L in retinopathy group compared to
3.0 (1.02) mmoi!L in the contol group (P=0.005). There was a higher concentration of
serum cholesterol, triglyceride and LDL in patients with severe retinal hard exudates
compared to those with mild and moderate,however it was not statistically significant
(P= 0.082, 0.116, 0.218) respectively. The mean serum oxidized-LDL concentration was
higher in diabetic retinopathy with severe retinal hard exudates compared to mild and
xi
moderate. There was no statistically significant difference in the mean oxidized LDL
with other systemic diseases or duration of diabetes.
Conelusion: There was significant association between serum cholesterol and LDL with
diabetic retinopathy. However there was no association between serum lipid profile with
the severity of retinal hard exudates. Serum ox-LDL was also not associated with
diabetic retinopathy and other systemic co-morbidities in our study.
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