Hussain, Nik Hazlina Nik and Noor, Norhayati Mohd and Ismail, Saiful Bahari and Zainuddin, Nur Amirah and Sulaiman, Zaharah
(2021)
Metoclopramide for milk production in
lactating women: a systematic review and meta-analysis.
Background: Breastfeeding is recognized as the optimal form of nutrition for the physical and neurological development of infants and is considered the most significant way to prevent child mortality. This study aimed to assess the effectiveness of metocl.
(Submitted)
Abstract
Background: Breastfeeding is recognized as the optimal form of nutrition for the physical and neurological development
of infants and is considered the most significant way to prevent child mortality. This study aimed to assess
the effectiveness of metoclopramide for enhancing milk production in lactating women.
Methods: We searched the Cochrane Central Register of Controlled Trials and MEDLINE for randomized controlled
trials comparing metoclopramide with a placebo, no treatment, or other galactagogue drugs. We included
breastfeeding women with term or preterm infants.
Results: We retrieved 164 records from our search of the electronic databases and 20 records from other sources.
Eight trials involving 342 lactating women that used metoclopramide were included in this review after assessing
the eligibility criteria. The meta-analysis of these trials revealed that metoclopramide did not increase the milk volume
of the intervention groups compared to that of the control groups. There was a significant increase in the serum
concentrations of prolactin when the mothers were administered metoclopramide. No significant adverse
events were reported.
Conclusion: Metoclopramide did not improve milk production in lactating women. Therefore, we do not recommend
using metoclopramide to increase milk production in lactating women.
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