Fuad, Wan Ezumi Mohd and Sulaiman, Siti Amrah and Islam, Mohamad Nazrul
(2009)
Evaluation of the teratogenicity of aqueous extract
of labisia pumila var. alata in rats.
Evaluation of the teratogenicity of aqueous extract of labisia pumila var. alata in rats.
(Submitted)
Abstract
A dose range study. to assess the teratogenic potential of aqueous extract of Labisia
pumila var. alata (Kacip Fatimah) was conducted in rodents. The extract at doses
of 0 (control), 2, 20, 200, 400, 1000 mglkglday were respectively administered by
gavaging to 6 groups of pregnant Sprague Dawley rats from day 6 through day 16
of pregnancy and sacrificed on day 21. No significant agent-related effects including
changes in maternal body weight (MBW) nor weight gain were observed. The
corrected maternal body weights (CMBW) were slightly higher in animals receiving
low dose extracts (2 mglkglday) as compared to all groups of animals. However,
body weight differences were not statistically significant .. Gravid uterine weight,
number of corpora lutea, number of implantation sites, percentage of foetal
resorptlons, number of life foetuses, foetal weight and foetal sex ratio showed i10
significant differences among all group animals. None of the foetuses from all dams
showed evidence of external congenital malformations. These findings may suggest
that aqueous extracts ofLabisia pumila var. alata up to 1000 mglkglday ~tatlstically
do not show any significant teratogenic effects In rats but do affect the maternal
body weight and this is dose dependent
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