Mutalib, Asrul Fahmi Abdul
(2008)
Sequence polymorphism of mitochondrial dna hvs-11 region
of chinese population of peninsular Malaysia.
Other.
Universiti Sains Malaysia.
(Submitted)
Abstract
The mitochondrial DNA hypervariable segment II (HVS-Iij sequence variations from
various populations are less published compared to hypervariable segment I (HVS-1). The
primary objective of this study is to determine the HVS-II sequence polymorphisms of the
Chinese population and then use the data acquired to classify the mtDNA haplogroup. The
study was carried out by using 3 7 samples from Chinese population of Peninsular Malaysia.
The HVS•II of the mtDNA control region was amplified and sequenced. Polymorphisms
were reported by aligning each sequence to the Cambridge Reference Sequence (CRS). A
total of 57 polymorphisms were detected, which encompass 27 transitions and 20
transversion. By using the HVS•II sequence data, 22 samples were classified into
superhaplogroup M (M7b 1, M8a, G2a, DSa, D4 and C) and 3 samples were classified into
superhaplogroup N (R9a and N9a). The unclassified samples need further analysis for their
classification.
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