Chyi, Liew Chyi
(2006)
Polymorphism of STRs 075820, 0135317, and 0165539 in Dusun population.
Other.
Universiti Sains Malaysia.
(Submitted)
Abstract
DNA typing of short tandem repeat (STR) loci is routinely done for DNA analysis in
forensic practices. This PCR .. based technique is useful for paternity and personal
identification testing. STR technology evaluates the specific loci that found in nuclear
DNA which are highly polymorphic in nature. These highly polymorphic markers can be
typed from DNA derived from various forensic biological samples. Once the multiple
locus profile is established, it intensifies the discrimination between one DNA profile and
another. As the number of analyzed loci increases, the probability of a second, unrelated
person, excluding identical twins, having the same profile becomes ever unlikely.
Therefore, the population data on the distribution of allele frequencies are essential for the
estimation of probability of certainty. It would be of benefit for the forensic community to
make data on the genetic variation of selected validated loci in as many populations as
possible. This study examined the population frequency and genetic diversity of three
autosomal STR loci, D7S820, D13S371, and Dl6S539 in Dusun population of Eastern
Malaysia. In this study, there was no detectable departure from the Hardy .. Weinberg
equilibrium observed for the three STRs loci by the Chi .. square test. The data obtained in
present study have been compared with STRs data of various population groups reported
in the literature.
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