Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice

Kumar, Venugopalan Santhosh (2018) Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice. PhD thesis, Universiti Sains Malaysia.

[img]
Preview
 PDF
Download (1MB) | Preview

Abstract

Present study was aimed to evaluate the potential immunostimulant activity of NAcetylglucosamine (NAG) from Azadirachta indica leaves in mice. The hexane, chloroform, methanol and aqueous extracts of A. indica leaves were prepared and its immunostimulant activity was studied. The aqueous extract of A. indica leaves (AEAIL) showed significant (P< 0.001) higher immunostimulant activity than other extracts. Hence, isolation of possible phytoconstituent(s) from AEAIL was carried out and the N-Acetylglucosamine (NAG) was isolated. The NAG was administered at 266, 400 and 800 μg/kg of mice, intraperitoneal route weekly for 4 weeks to evaluate immunostimulant activity.

Item Type: Thesis (PhD)
Subjects: Q Science > QR Microbiology
Divisions: Pusat Penyelidikan Dadah dan Ubat-ubatan (Centre for Drug Research) > Thesis
Depositing User: Mr Aizat Asmawi Abdul Rahim
Date Deposited: 27 Oct 2020 09:24
Last Modified: 27 Oct 2020 09:24
URI: http://eprints.usm.my/id/eprint/47797

Actions (login required)

View Item View Item
USM Repository is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.
Share