Hassan, Mohd Hashim Mohd and Al-Mahmood, Abu Kholdun
(2005)
The insulin sensitivity of non-obese Malay subjects and the relationship
between hyperlipidemia with insulin sensitivity.
The insulin sensitivity of non-obese Malay subjects and the relationship between hyperlipidemia with insulin sensitivity.
(Submitted)
Abstract
Introduction: Hyperlipidaemia and insulin resistance may have a relationship. Most of the
previous studies looked at insulin resistance in hyperlipidaemic subjects who were also
obese. So influence of obesity and hyperlipidaemia acted simultaneously in the genesis of
insulin resistance.
Objective: To determine insulin sensitivity and secretory status of non-obese
normoglycemic Malay subjects, and to study the relationship between hyperlipidemia and
insulin sensitivity in such population.
Methodology: A cross sectional study on 246 non-obese (BMI<25kg/m2
, waist
circumference male<102cm, female <88cm.) and non-diabetic subjects age between 30-
60 years was carried out. Fasting plasma glucose, fasting insulin and lipid profile were
done. Insulin sensitivity and secretory status was calculated using homeostasis model
assessment (HOMA) software (HOMA%S, HOMA%B and HOMA-IR). The subjects
were divided into two groups according to their lipid status (128 normolipidemic and 118
hyperlipidemic) and their insulin sensitivity was compared.
Results: The hyperlipidemic subjects showed substantially lower insulin sensitivity and
higher insulin resistance in comparison to normolipidemic subjects. The mean of
HOMA%S of hyperlipidemic and normolipidemic subjects were 80 and 155 (p<.0001)
respectively. The mean of relative insulin resistance HOMA-IR was 2.66 in
hyperlipidemic subjects which was 1.05 in normolipidemic subjects. Insulin secretory
status (HOMA%B) oftwo group were 178 and 116 respectively.
Conclusion: Insulin sensitivity of otherwise healthy non-obese hyperlipidemic
subjects is lower than normolipidemic subjects. The B cells of hyperlipidemic subjects
have to work more to compensate lowered insulin sensitivity.
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