Rohani, Mohd Fazrin Mohd
(2019)
Utilisation Of Standardized Uptake Value Maximum (SUVMAX) In Single Photon Emission Computed Tomography / Computed Tomography (SPECT/CT) To Differentiate Between Metastatic Vs Degenerative Joint Disease Of The Spine In Bone Scan For Prostate Cancer Patients.
Masters thesis, Universiti Sains Malaysia.
Abstract
Objective. Qualitative interpretation in bone scan is often complicated by the presence
of degenerative joint disease (DJD) especially in the elderly patient. The aim of this study
is to compare objectively 99mTc-MDP tracer uptake between DJD and osseous metastases
of the spine using semi-quantitative assessment with SPECT SUV.
Subjects and Methods. Bone scan with SPECT/CT using 99mTc-MDP were performed
in 34 patients diagnosed with prostate carcinoma. SPECT/CT were performed based on
our institutional standard guidelines. SUVmax based on body weight in 238 normal
vertebrae visualized on SPECT/CT were quantified as baseline. A total of 211 lesions in
the spine were identified on bone scan. Lesions were characterized into DJD or bone
metastases based on its morphology on low dose CT. Semi-quantitative evaluation using
SUVmax were then performed on 89 DJD and 122 metastatic bone lesions.
Results. The mean SUVmax for normal vertebrae was 7.08 ± 1.97, 12.59 ± 9.01 for DJD
and 36.64 ± 24.84 for bone metastases. The SUVmax of bone metastases were
significantly greater than DJD (p value <0.05). To assess for diagnostic accuracy, receiver
operating characteristic (ROC) curve was performed. The area under the curve (AUC)
was found to be fairly high at 0.874 (95% CI: 0.826-0.921). The cut-off SUVmax value
≥ 20 gave a sensitivity of 73.8% and specificity of 85.4% in differentiating bone
metastases from DJD.
Conclusion. SPECT SUVmax was significantly higher in bone metastases than DJD.
Semi-quantitative assessment with SUVmax can complement qualitative analysis. A cutoff
SUVmax of ≥ 20 can be used to differentiate bone metastases from DJD. However,
it is not feasible to be applied clinically due to the considerable overlap of SUVmax
between DJD and bone metastases.
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