Rahman, Husna Syakirah Ab and Ibrahim, Wan Suriyani Wan and Ismail, Norzila and Ismail, Tuan Nadrah Naim Tuan and Salleh, Siti Farhanah Mohd and Pak, Michael Kai Wong and Samad, Mohd Ridzuan Abdul and Hashim, Mohd Nizam Md (2018) Phytocompounds of Anonna muricata leaves extract and cytotoxic effects on breast cancer cells. Asian Pacific Journal of Tropical Medicine, 11 (12). pp. 659-665. ISSN 1995-7645
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Abstract
Objective: To identify the phytochemical compounds from Annona muricata (A. muricata) and to determine their in vitro anti-proliferative activities against breast cancer cells, MCF7 and MDA-MB-231. Methods: A. muricata leaves were successively extracted by soxhlet method using n-hexane, ethyl acetate and methanol, and decocted with water. Each extract was analysed by gas chromatography mass spectrometry (GCMS) and characterized with Wiley and NIST library searches. Anti-proliferative activity of each extract was evaluated on MCF7 and MDA-MB-231 breast cancer cells using MTT assay. Results: The GCMS analysis of different solvent extracts of A. muricata leaves showed presence of different chemical groups of compounds such as steroids, terpenoids, phenolic compounds, sugars, sugars alcohol and others including vitamin E. Ethyl acetate leaves extract exhibited the lowest IC50 value on the MDA-MB-231 breast cancer cell and n-hexane leaves extract showed the the lowest IC50 value on the MCF-7 breast cancer cell. Conclusion: Steroids and phenolic compounds were the main phytocompound groups identified from all A. muricata leaves extracts. The antiproliferative activity of n-hexane and ethyl acetate extract towards breast cancer MCF7 and MDA-MB-231 respectively might be due to the presence of biologically active compounds in the extracts, hence, providing some scientific evidences of the effectiveness of its traditional usages.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC254-282 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Article Zoom Profil Pakar (Expert Profile) > Norzila Ismail (Medical Sciences) |
| Depositing User: | Administrator Automasi |
| Date Deposited: | 11 Mar 2020 08:16 |
| Last Modified: | 11 Mar 2020 08:16 |
| URI: | http://eprints.usm.my/id/eprint/46485 |
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