Amran, Mohd Hanif
(2018)
Correlation between Magnetic Resonance (MR)
Volumetry and Apparent Diffusion Coefficient
(ADC) Value of Hippocampal Formation in
Medically Intractable Temporal Lobe Epilepsy.
Masters thesis, Universiti Sains Malaysia.
Abstract
Objective:
The purpose of this study is to determine volumetry values of the Hippocampal
Formation in refractory Temporal Lobe Epilepsy patients comparing with volumetry
values of normal individual, correlating the volumetry values with ADC (Apparent
Diffusion Coefficient) values for detecting hippocampal formation abnormalities in
patients with medically intractable temporal lobe epilepsy (MITLE). Other than that is
to correlate MR volumetry values with duration of illness in refractory Temporal Lobe
Epilepsy (TLE) patients.
Background: In this study, we compared the hippocampal volume of patients with
underlying medically intractable temporal lobe epilepsy (MITLE) and normal subjects
and to look for correlation between the hippocampal volume, ADC values and duration
of illness.
Methodology: A total of 28 participants were recruited for the present study; there were
14 participants in control and TLE-positive group, respectively. MR images were
evaluated for hippocampal volumetric calculation and was correlated with ADC maps
and duration of illness. Mean and SDs were obtained for each measurement, and level
of significance was determined.
Analysis of mean volumetry, ADC values were performed using PASW version 18. We
used an independent t-test to investigate group differences in mean hippocampal
volumetric value. Pearson correlation was used to examine relationships between mean
hippocampal volumetric value and duration of illness, also as mean hippocampal
volumetric value with ADC value.
Results:
There was no significant difference shown between the left and right hippocampal MR
volumetric values in the control group. However, significant differences were shown in
hippocampal MR volumetric values, were found between control and TLE-ipsilateral
sites. There are also significant differences were shown in hippocampal volumetric
values, were found between both sides of hippocampus in right and left TLE patients.
The hippocampal MR volumetric values did not show significant correlation with the
duration of illness. There was significant correlation between hippocampal volumetric
value and ADC.
Conclusions:
Hippocampal volumetry have the capabilities to detect changes in the hippocampal
formation and to lateralize the seizure focus in patients with TLE. There is no
significant correlation between hippocampal volumetric values with duration of illness.
There was significant correlation between hippocampal volumetric values with ADC.
Actions (login required)
 |
View Item |
