In vivo study of a locally manufactured hydroxyapatite-based material as bone replacement material

Razak, Noor Hayati Abdul and Samsudin, Ab. Rani and Omar, Nor Shamsuria (2004) In vivo study of a locally manufactured hydroxyapatite-based material as bone replacement material. In vivo study of a locally manufactured hydroxyapatite-based material as bone replacement material. (Submitted)

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Abstract

The objective of the study is to evaluate the osteoconductive, osteoinductive and biocompatibility properties of a locally produced dense hydroxyapatite (HA) as bone replacement material in mandibles. The study was carried out on 8 New Zealand White rabbits. Defects were created in the mandible of a rabbit model whereby the right side was implanted with HA while the left side was left empty to act as a control. The dense HA blocks with the pore size of < 5J.1m promotes bone ingrowth as early as 4 weeks when viewed by the topographic method. Both the implant and control sites were evaluated clinically and histologically at 4, 12, 20, 22 weeks interval. Enhancement of osteoconduction was evident by the presence of abundant capillaries, perivascular tissue and osteoprogenitor cells of the host accounting for the new bone filling the gap and remodelling taking place. This study demonstrated that the dense HA exhibits excellent biocompatibility as noted by the complete absence of reactive cells. HA also promotes osteoconduction. It appears that this locally manufactured HA has the potential to be a valuable replacement material for maxillofacial reconstructive surgery and orthopaedic surgery.

Item Type: Article
Uncontrolled Keywords: Bone replacement material
Subjects: R Medicine > RK Dentistry
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Pergigian (School of Dental Sciences) > Article
Depositing User: Mr Abdul Hadi Mohammad
Date Deposited: 27 Feb 2020 04:01
Last Modified: 27 Feb 2020 04:01
URI: http://eprints.usm.my/id/eprint/46364

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