Nordin, Nor Hafizah Haji
(2004)
Effect of vitex smilex on pregnant rats.
Effect of vitex smilex on pregnant rats.
(Submitted)
Abstract
The herbal plant Vitex smilex was evaluated for it effects on pregnant albino
rats. 54 female rats were used for this study. The rats were divided into control group
and treatment group. Extract of the plant was prepared with distilled water by using
sohlet apparatus in pharmacology laboratories. The plant extract was administered
orally by means of a gavage from day 1 to 7 of pregnancy. Out of 12 rats in each
group, 6 were laparotomized under ether anaesthesia on day 1 0 of pregnancy. Both
the horns of uterus was observed for number of fetus or resorption site sites and
allowed to full term pregnancy. Number of fetus was compared with the number of
pups delivered. The remaining 6 rats were used for histological study to confirm the
activity of the extract. Result of the study showed that aqueous extract of Vitex smilex
did not show efficacy as an antifertility agent. However, late resorbtion was observed
in rat, which treated with 1 Omg/kg and 1 OOmg/kg of Vitex smilex extract.
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