Yusoff, Khairiah Mat
(2018)
The effect of modified alternate day calorie restriction on non-alcoholic fatty liver disease (NAFLD).
Masters thesis, Universiti Sains Malaysia.
Abstract
Introduction: NAFLD is a serious medical issue worldwide. Various diet modifications
had been implemented to improve liver steatosis. SWE is an emerging technique that offers
non-invasive method of liver steatosis assessment. In this study, we aimed to compare the
liver steatosis grading and liver elasticity among NAFLD patients who underwent 8 weeks
of MADCR.
Methodology: Using the Aixplorer® ultrasound, liver ultrasound of 39 subjects (32
interventional and 9 control subjects) were performed. Liver steatosis grading, fibrosis
grading and shear wave elastography of all patients were acquired. Liver steatosis and liver
elasticity level pre and post pre intervention were compared. Correlation of the liver
steatosis and gradings were analysed using Kendall b tau analysis.
Results: The mean liver steatosis grade and fibrosis level of the 30 participants in the
intervention group were significantly reduced after MADCR (modified alternate day
calorie restriction) programme. Our result showed that 10 patients had improved liver
steatosis grading, whereby 8 patients improve from grade 2 to grade 1 and 2 patients from
grade 1 to grade 0. Our study showed significant mean difference of liver elasticity in
intervention group after MADCR (p value <0.001). From the analysis of the readings from
all the participants (n=78), the SWE values showed significant weak correlation with the
steatosis grading (0-3) of the fatty liver (P value 0.013).
Conclusions:
MADCR is beneficial to improve liver steatosis. SWE is a useful and reliable method to
assess liver elasticity after intervention.
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