Yusof, Wan Yuhana W Md
(2017)
Survival analysis on adult extremity soft tissue sarcoma : a single institution study of 10 years duration.
Masters thesis, Universiti Sains Malaysia.
Abstract
Soft tissue sarcoma is one of the commonest orthopaedic related malignancy.
Approximately 80% of sarcoma arises from soft tissue and 20 % from bone⁸ ³. However, from the
general point of view, soft tissue sarcoma is one of the rarest malignancies with incidence reported
was less than 1%. Its classification is based on the direction of the differentiation of the soft tissue
either collagen (fibrous tissue), fat or cartilage for instance.
Several demographic factors and a few other possible prognostic factors have been
demonstrated previously that may influence the patients’ survival. This study involved 128 patients
for 10 years duration (1st January 2001- 31st January 2010) from one of the tertiary center for
orthopaedic oncology in the country. Besides demographic studies, the prognostic clinical
characteristics were assessed for differences in overall survival by using Kaplan Meier method as
well as Cox proportional hazard regression.
From this study, it was found the overall median survival time was 10 years with 5- year
overall survival of 58%. No demographic results were statistically significant in affecting the
overall survival (age, sex, sites of tumor, and subtypes, p-value >0.05). Treatments of soft tissue
sarcoma for example limb salvage or amputation surgery, pre- and post- operative chemotherapy
and radiotherapy, as well as outcome of the tumor which was second malignancy were all not
statistically significant as well (p- value >0.05).
Pulmonary and distant (non-pulmonary) metastasis, and local recurrence were the
prognostic factors that significantly affect the overall survival (p <0.001). Nevertheless, after a
multivariate analysis, only pulmonary (CI:3.08, p <0.001) and distant (non-pulmonary) (CI:2.30,
p <0.004) metastasis were significantly associated with survival.
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