Enhanced Production Of Poly (3-Hydroxybutyrate-Co-4-Hydroxybutyrate) With High 4hb Unit Composition Using Transformant Cupriavidus sp.USMAA1020

Hambali, Norhafini (2017) Enhanced Production Of Poly (3-Hydroxybutyrate-Co-4-Hydroxybutyrate) With High 4hb Unit Composition Using Transformant Cupriavidus sp.USMAA1020. Masters thesis, Universiti Sains Malaysia.

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Abstract

Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] copolymer is one of emerging biopolymer which possess suitable properties to be applied in medical applications. P(3HB-co-4HB) with high 4HB unit is favorable as this enhance the biocompatibility and mechanical properties of this copolymer as implantable and absorbable biomaterial. However, biosynthesis of P(3HB-co-4HB) in single-stage cultivation produces low 4HB unit composition with low productivity. Cupriavidus sp. USMAA1020, a bacterium isolated from Malaysian environment, was capable to synthesize P(3HB-co-4HB) with different 4HB unit compositions but only to a maximum of 70 mol% through single-stage cultivation.

Item Type:	Thesis (Masters)
Subjects:	R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions:	Institut Farmaseutikal & Nutraseutikal Malaysia (Malaysian Institute of Pharmaceuticals & Nutraceuticals > Thesis
Depositing User:	ASM Ab Shukor Mustapa
Date Deposited:	18 Sep 2019 01:04
Last Modified:	18 Sep 2019 01:04
URI:	http://eprints.usm.my/id/eprint/45453

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