Arif, Mohd Faizal Mohd
(2017)
Quality of life and its associated factors among knee osteoarthritis patients.
Masters thesis, Universiti Sains Malaysia.
Abstract
Introduction: Osteoarthritis is the most common form of arthritis around the
globe. The aim of knee osteoarthritis treatment is to alleviate pain, delay
progression of osteoarthritis, improvement in mobility, walking as well as
improvement in the quality of life. Despite the clear goal of treatment mentioned,
quality of life is the least considered or often neglected aspect in the overall
management of patients with knee osteoarthritis.
Objectives: To determine the quality of life and its associated factors among
knee osteoarthritis patients.
Methodology: A cross-sectional study was conducted from 1st June 2014 until
30th October 2014 at the orthopaedic clinic in Universiti Sains Malaysia Hospital
(HUSM). Systematic random sampling was applied based on attendance list in
orthopaedic clinic, HUSM. A set of questionnaires which includes case report
form and the Malay version of Osteoarthritis Knee and Hip Quality of Life
(OAKHQOL) questionnaire was given to patients before determining their body
mass index (BMI) and reviewing their latest knee radiograph. Data analysis was
done using SPSS Version 22. The overall quality of life among knee osteoarthritis
were expressed by using mean OAKHQOL score for each domain while the
associated factors that affecting the quality of life were analysed by using general
linear regression analysis.
Result: The mean quality of life among patient with knee osteoarthritis were
average. The worse domain was a social functioning domain with a mean scoreof 59.1 (SD 26.31) and the least affected domain was mental health domain with
the mean score of 35.7 (SD 22.42). Increasing BMI was consistently associated
with worsening of almost all domains of OAKHQOL which include physical activity
(CI 0.50, 1.68), mental health (CI 0.17, 1.49), pain (CI 0.24, 1.58) and
professional activity (CI 0.34, 1.94) except for social support which showed an
improvement with increasing BMI (CI -2.39, -0.63). Social functioning was not
associated with any studied variables. An ever-used glucosamine associated with
worsening score on physical activity (CI 1.51, 14.99), mental health (CI 1.79,
17.17) and pain (CI 2.98, 18.68) domains. Longer duration of knee osteoarthritis
and bilateral involvement of knee were both associated with worse sexual activity
(CI 0.42, 2.59); (CI 3.68, 20.37) and relationship item score (CI 0.28, 2.48); (CI
2.83, 19.79). Higher education status appears to have a better score in mental
health (CI -33.24, -7.42) and pain (CI -32.11, -5.75). domain. An ever used
NSAIDs was associated with poorer score in sexual activity item (CI 0.20, 17.11).
Higher grade of knee osteoarthritis by Kellgren Lawrence grading of knee
osteoarthritis have worse professional activity item score (CI 0.03, 24.49).
Conclusion: The quality of life among patients with knee osteoarthritis in this
study was average. Increasing BMI was consistently associated with worsening
of almost all domains of OAKHQOL, except for social functioning. Social
functioning was not associated with any studied variables. Variables that had an
association with at least one domain of OAKHQOL were education status, grade
of knee osteoarthritis, medication usage (glucosamine or NSAIDs), duration of
knee pain and knee involvement (unilateral or bilateral).
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