Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates

Ooi, Wei Yang (2012) Synthesis And Characterization Of Thermoresponsive Poly(N-Isoproylacrylamide)-DNA Bioconjugates. PhD thesis, Universiti Sains Malaysia.

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Abstract

Bioconjugates (PNIPAAm−graft−DNA) of poly(N-isopropylacrylamide) (PNIPAAm) grafted with single-stranded (ss) DNA were synthesized via radical copolymerization. The bioconjugates self-assembled above its lower critical solution temperature (LCST) in aqueous solution to form micelle-like colloidal nanoparticles. When the ssDNA of the nanoparticle hybridizes with complementary DNA, the particles aggregate above a certain threshold of salt concentration with drastically increased turbidity in solution.

Item Type:	Thesis (PhD)
Subjects:	Q Science > QH Natural history > QH1 Natural history (General - Including nature conservation, geographical distribution)
Divisions:	Pusat Pengajian Sains Kajihayat (School of Biological Sciences) > Thesis
Depositing User:	ASM Ab Shukor Mustapa
Date Deposited:	05 Jul 2019 02:18
Last Modified:	05 Jul 2019 02:18
URI:	http://eprints.usm.my/id/eprint/44882

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