Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models

Kamaruzaman, Nur Azzalia (2018) Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models. PhD thesis, Universiti Sains Malaysia.

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Abstract

β-carboline is known for its numerous traditional uses and has been widely investigated for various health indications. In particular, recently β-carboline has shown some promising findings in the field of anticancer. Hence this study investigates the potential anticancer activity of β-carboline compounds using in vitro models. Thirty synthesized β-carboline compounds were tested using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for anticancer activity and selectivity index (SI) against four human cancer (colon HT-29, cervical HeLa, liver Hep G2 and leukemia K562) and two non-cancer (mouse embryo fibroblasts BALB/c3T3 and human foreskin fibroblasts Hs27) cell lines.

Item Type:	Thesis (PhD)
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	Pusat Penyelidikan Dadah dan Ubat-ubatan (Centre for Drug Research) > Thesis
Depositing User:	ASM Ab Shukor Mustapa
Date Deposited:	18 Apr 2019 02:42
Last Modified:	18 Apr 2019 02:42
URI:	http://eprints.usm.my/id/eprint/44126

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