Dezhao, Sai
(2016)
Comparison of macular thickness, retinal nerve fiber layer thickness and optic nerve head parameters in HbE/Beta thalassemia and control.
Masters thesis, Universiti Sains Malaysia.
Abstract
Introduction
HbE/ β-thalassemia is one of the hemoglobinopathy that commonly found in South East Asia
(SEA) and it has become a severe public health problem today. Apart from the pathological
anemia, they also share other common features like hepatosplenomegaly and craniofacial bony
deformities. Ocular biometry can be affected as well due to abnormal growth of the orbital bone.
Other than these, structure of the retina and the optic nerve may be altered in these patients.
Objective
To compare mean macular thickness, retinal nerve fiber layer (RNFL) thickness and optic nerve
head (ONH) parameters between HbE/ β-thalassemia group and control.
Methods
This is a cross-sectional study conducted in Hospital Universiti Sains Malaysia from June 2014
till March 2016. Patients with confirmed HbE/ β-thalassemia and healthy population were selected
based on the inclusion and exclusion criteria. Baseline macular thickness, RNFL thickness and
ONH parameters were measured by using Cirrus HD-OCT. Statistical analysis was performed
using SPSS version 22.0.
Results
A total of 132 participants were recruited (66 participants in HbE/ β-thalassemia group and 66
participants in control). There was no significant difference in mean macular thickness in between
the two groups. No significant different found in the mean RNFL thickness in between HbE/ β-
thalassemia and control. There was also no significant difference in ONH parameters between two
groups.
Conclusion
The study revealed that there was no significant differences in both mean macular thickness, RNFL
thickness and ONH parameters in between HbE/ β-thalassemia and normal population.
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