Sivagurunathan, Premala Devi
(2016)
The effect of honey cocktail supplement on macular thickness, retinal nerve fiber layes thickness and optic berve head parameters in post-menopausal women.
Masters thesis, Universiti Sains Malaysia.
Abstract
Introduction
Menopause is an integral part of a woman’s life. The clinical changes that occur during this
period of life not only involve vasomotor, genitourinary, sleep disturbances and mood changes
but also involve ocular structures such as tear film, lens, intraocular pressure, ocular blood flow
and the retina. Apart from hormone replacement therapy (HRT), many other alternative therapies
including honey showed promising effect in relieving menopausal symptoms, treating ocular
diseases and maintain ocular functions.
Objective
To compare mean macular thickness, retinal nerve fiber layer (RNFL) thickness and optic nerve
head (ONH) parameters with and without honey cocktail supplement in post-menopausal
women.
Methods
This is a prospective randomized controlled trial conducted in Hospital Universiti Sains Malaysia
between March 2014 and July 2015. A total of 60 post-menopausal women who fulfilled the
selection criterias were selected and randomized into 2 groups using randomized opaque
envelope technique “HONEY COCKTAIL” and “NO HONEY”. Baseline macular thickness,
RNFL thickness and ONH parameters were taken using Cirrus HD-OCT machine for both
groups by blinded trained personnel. Participants in the “HONEY COCKTAIL” group were
instructed to take honey cocktail from the honey cocktail sachets provided for a total of 3 months
duration. The dosing was 1 sachet containing 20 grams per day consumed straight from the
sachet without dilution. Participant in the “NO HONEY” group were not given any placebo.
After 3 months, the macular thickness, RNFL thickness and ONH parameters were repeated
using the same machine, same technique and by the same blinded medical personnel. Statistical
analysis was performed using SPSS version 22.0.
Results
A total of 60 participants were recruited (30 participants in each honey cocktail and no honey
group). The mean global macular thickness was significantly thicker in post-menopausal women
with honey supplement 3 months post supplement therapy (p = 0.002). There was also a
significant difference in the mean change of global macular thickness at 3 months post
supplement therapy between the 2 groups (p < 0.001). The mean global RNFL thickness was
significantly higher in post-menopausal women with honey supplement 3 months post
intervention (p = 0.033). There was also a significant difference in the mean change of global
RNFL thickness at 3 months post supplement therapy between the 2 groups (p < 0.001). There
were no significant difference in the ONH parameters in post-menopausal women with and
without honey cocktail supplement 3 months post supplement therapy. There was significant
difference in the mean change of rim area (p = 0.003), cup area (p = 0.001) and cup-disc-ratio (p
<0.001) at 3 months post supplement therapy between the 2 groups.
Conclusion
Honey cocktail was shown to be beneficial and protective in improving macular thickness,
RNFL thickness and ONH parameters in post-menopausal women.
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