Kurniawati, Fivy
(2013)
Explorative Study Of Adverse Drug Reactions And Drug-Resistant Tuberculosis Among Tuberculosis Patients In Hospital Pulau Pinang, Malaysia.
Masters thesis, Universiti Sains Malaysia.
Abstract
Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis
claimed for human life throughout history today become second leading infectious
diseases caused death after HIV-AIDS. Treatment of tuberculosis required
combination of anti-tuberculosis drug. Anti-tuberculosis adverse drug reactions
(ADRs) become important as longer use of these drugs. In addition to antituberculosis
ADRs, the presence of tuberculosis bacteria that resistant to anti
tuberculosis drug may complicate on tuberculosis treatment.
This study was a retrospective cross-sectional observation study. Research
subjects of this study were patients who were treated as active tuberculosis in Chest
Clinic, Hospital Pulau Pinang, Malaysia. The aim of the study was to investigate
anti-tuberculosis ADRs, drug-resistant tuberculosis (DR-TB), and all associate
factors related to ADRs and DR-TB, also patients’ treatment clinical outcomes.
Adverse drug reactions were detected from patients’ complains, clinical symptom,
laboratory test result, and any other related information and DR-TB detected from
patients’ sensitivity test result. Patients’ socio-demographic, medical history,
tuberculosis diagnosis and treatment, clinical sign and symptom of ADRs, laboratory
test result, sputum smear test, radiology test result, and other relevant information
were collected. Obtained data then exported to excel and analyzed by using
Statistical Package for Social Sciences (SPSS® version 15).
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