(Analysis of the proliferating cell nuclear antigen(PCNA) and Ki-67 as proliferating cell markers) Expressions in colorectal carcinoma at HUSM and its relationship with the duke staging system

Kamal, Meor Zamari Meor and Jaafar, Hasnan and Ali, Kholip and J, Rosli (2001) (Analysis of the proliferating cell nuclear antigen(PCNA) and Ki-67 as proliferating cell markers) Expressions in colorectal carcinoma at HUSM and its relationship with the duke staging system. In: (Analysis of the proliferating cell nuclear antigen(PCNA) and Ki-67 as proliferating cell markers) Expressions in colorectal carcinoma at HUSM and its relationship with the duke staging system. (Submitted)

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Abstract

Proliferating cell nuclear antigen (PCNA) and Ki-67 are the two important molecules expressed by the proliferating cells. They are important during the DNA synthesis. We applied the antibodies (using DAKO EPOS system) against these two proteins to a series of 54 cases of colorectal adenocarcinoma of various Dukes' stages in order to observe the degree of expressions and their relationship with Dukes' stage. Our study showed, regardless of the Dukes' stage almost all cases are strongly expressed PCNA. However we failed to demonstrate the expression of Ki-67. We conclude that expression of PCNA is strong in colorectal carcinoma but the degree of expression has no relationship with the Dukes' stage. Expression of Ki-67 is probably best seen if we use fresh tissue rather than formalin fixed paraffin embedded tissue.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Colorectal carcinoma, EPOS system, Immunohistochemistry
Subjects: R Medicine > RB Pathology > RB151-214 Theories of disease. Etiology. Pathogenesis
Divisions: Kampus Kesihatan (Health Campus) > Pusat Pengajian Sains Perubatan (School of Medical Sciences) > Conference or Workshop Item
Depositing User: Mr Abdul Hadi Mohammad
Date Deposited: 20 Mar 2020 04:50
Last Modified: 20 Mar 2020 04:50
URI: http://eprints.usm.my/id/eprint/42546

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