Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities

Ngai, Mun Hong and Sirat, Hasnah (2004) Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities. In: The 4th Annual Seminar of National Science Fellowship NSF 2004 Proceedings. Penerbit Universiti Sains Malaysia, Pulau Pinang, Malaysia, pp. 181-186.

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Abstract

Xanthorrhizol (1) is a bisabolane-type sesquiterpenoid obtained as the main constituent of the rhizome oil of temu lawak, Curcuma xanthorrhiza, which has been utilised as a tonic in Indonesia and as a choleretic drug in Europe. As regards to its bioactivities, it has been shown that xanthorrhizol (1) possessed antifungal activity against Candida albicans (MIC=68.75 μg/mL) and cytotoxic against human nasopharyngeal carcinoma cell line (KB, EC50 = 4.90 μg/mL) (Mata et al., 2001). Although the synthesis of 1 has been extensively studied, the chemistry of this compound has only be studied in a limited extent.

Item Type:	Book Section
Subjects:	Q Science > Q Science (General) > Q179.9-180 Research
Divisions:	Koleksi Penganjuran Persidangan (Conference Collection) > Annual Seminar National Science Fellowship (NSF)
Depositing User:	Puan Sukmawati Muhamad
Date Deposited:	15 Oct 2018 07:59
Last Modified:	02 Nov 2018 03:21
URI:	http://eprints.usm.my/id/eprint/42516

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