Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine

Chitneni , Mallikarjun (2010) Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine. PhD thesis, Universiti Sains Malaysia.

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Abstract

There are approximately 40% of new drug molecules discovered and some drugmolecules that are available in the market, having poor bioavailability due to poorsolubility and/or poor permeability. The present study aimed at formulating a selfmicroemulsifying drug delivery system (SMEDDS) using two BCS class IV drugs, namely sulpiride and norfloxacin. Sulpiride is a P-gp substrate and norfloxacin is a substrate of MRP2, BCRP and an unknown efflux pump.

Item Type: Thesis (PhD)
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis
Depositing User: ASM Ab Shukor Mustapa
Date Deposited: 05 Sep 2018 02:36
Last Modified: 12 Apr 2019 05:26
URI: http://eprints.usm.my/id/eprint/41728

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