Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells

Chew , Guat Siew (2010) Molecular Mechanism Of Acute Phase Response : Identification Of Signal Transduction Pathways Mediating Cytokine Inhibitory Effect On Human Peroxisome Proliferator Activated Receptor Alpha (PPARa) In Liver Cells. PhD thesis, Universiti Sains Malaysia.

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Abstract

Cytokines, like IL-6, play an important role in triggering the acute phase response (APR) of the body to injury and inflammation. The dynamics of expression and interaction of the IL-6 signalling pathway components in the regulation of peroxisome proliferator-activated receptor alpha (PPARα) during APR remain to be properly identified. In this study, we determined that three possible potential signaling pathways, JAK-STAT, PI3K and MAPK (p38 and ERK1/2) which derived from the upstream JAK and SHP2 components of the IL-6 signalling were involved in IL-6-inhibitory effect on PPARα gene expression.

Item Type:	Thesis (PhD)
Subjects:	Q Science > QH Natural history > QH1 Natural history (General - Including nature conservation, geographical distribution)
Divisions:	Pusat Pengajian Sains Kajihayat (School of Biological Sciences) > Thesis
Depositing User:	ASM Ab Shukor Mustapa
Date Deposited:	05 Sep 2018 01:55
Last Modified:	12 Apr 2019 05:26
URI:	http://eprints.usm.my/id/eprint/41719

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