Ghaith, Nada Faisal Zaki
(2010)
Evaluation Of Combined Metformin-Lovastatin Therapy In The Treatment Of Diabetic Type 2 Patients With Dyslipidemia In Hospital Pulau Pinang.
Masters thesis, Universiti Sains Malaysia.
Abstract
Diabetes type 2 is characterized by the presence of insulin resistance which
frequently co-exists with multiple cardiovascular risk factors. Dyslipidemia
is a well-recognized and modifiable risk factor that should be identified and
treated aggressively to prevent the onset and prognosis of cardiovascular
disease. This study aimed to assess the clinical outcomes behind the usage
of metformin and lovastatin in the treatment of diabetes type 2 patients with
dyslipidemia. Furthermore, an evaluation of difference in therapeutic
response was done according to race and gender. A retrospective
observational study was performed at the outpatient clinic of Hospital Pulau
Pinang, Malaysia. Demographic, medication profile, and laboratory tests
information were collected. Data were analyzed by using Statistical Package
of Social Sciences (SPSS) program version 15. From 873 medical records,
only 501 patients met the inclusion criteria of this study. Females constituted
55.9%, while 44.1% were males. Racial distribution showed that Chinese
were 41.7%, Malay 34.3% and Indians 24%. Significantly, Chinese showed
the highest percentage (97.5%) of controlled HDL levels. Unlike males,
females demonstrated the highest mean TC and HDL values (5.40 ± 1.09
mmol/l and 1.32 ± 0.29 mmol/l respectively) significantly.
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