Interaction of sympathetic nervous system and renin angiotensin system in systemic circulation of cardiac hypertrophic rat model with gα protein expression interface.

Hussain, Nurjannah Mohamad (2010) Interaction of sympathetic nervous system and renin angiotensin system in systemic circulation of cardiac hypertrophic rat model with gα protein expression interface. Masters thesis, Universiti Sains Malaysia.

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Abstract

Penyelidikan ini mengkaji kaitan di antara sistem saraf simpatetik (SNS) dan sistem renin angiotensin (RAS) di dalam hipertrofi jantung. Kajian hemodinamik dilakukan untuk menilai respon vasokonstriksi adrenoseptor (iaitu adrenoseptor α1 dan β1) dan reseptor angiotensin II jenis 1 (AT1) untuk memahami peranan fungsi SNS dan RAS dengan menggunakan model tikus hipertrofi jantung. Selanjutnya, penyelidikan ekspresi mRNA protein Gα melalui real-time PCR (RT-PCR) juga dilakukan untuk menilai beberapa isotype daripada 3 kumpulan protein Gα yang berbeza iaitu protein Gαs, Gαi dan Gαq/11 pada jantung tikus. The present study investigates the interrelation between sympathetic nervous system (SNS) and renin angiotensin system (RAS) in cardiac hypertrophy. Haemodynamic studies were performed to evaluate the vasoconstriction responses of adrenoceptors (i.e. α1- and β1- adrenoceptors) and angiotensin II type 1 receptors (AT1) to understand the functional role of SNS and RAS respectively using the cardiac hypertrophic rat model.

Item Type:	Thesis (Masters)
Subjects:	R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions:	Pusat Pengajian Sains Farmasi (School of Pharmacy) > Thesis
Depositing User:	Mr Erwan Roslan
Date Deposited:	11 Jul 2018 07:16
Last Modified:	26 Jul 2018 07:26
URI:	http://eprints.usm.my/id/eprint/40986

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