Periayah, Mercy Halleluyah
(2015)
Understanding Platelet Thrombogenicity Cascade
Of The Biodegradable Chitosan Derivatives
In Von Willebrand Disease In Vitro.
PhD thesis, Universiti Sains Malaysia.
Abstract
Biobahan kitosan diperolehi daripada cengkerang hidupan laut mempunyai potensi
yang besar bagi kegunaan klinikal kerana ia dapat bertindak balas dengan sel-sel
platelet secara bebas untuk membantu proses pembekuan darah. Penyelidikan ini
mengesahkan keupayaan biobahan kitosan untuk merangsangkan mekanisma platelet
dari penderma darah normal dan pesakit von Willebrand disease (vWD) in vitro.
Chitosan has become one of the most promising local hemostatic agents because it is
of particular interest as it functions independently on platelets and normal clotting
mechanisms. The present study was designed with the aim to test the ability of the
mechanisms of blood platelets towards the action of biodegradable chitosan in
normal donors and von Willebrand disease (vWD) patients in vitro.
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